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At the beginning of 2020, when everyone was preparing for the Lunar New Year, Wuhan suddenly announced the closure of the city on the day before New Year's Eve. This blockade of a large city with a population of 11 million is "unprecedented" in the history of public health. But the matter did not end, it was just the beginning. The world has completely changed over the past six months. The novel human coronavirus (SARS-CoV-2) has spread out in various parts of the world, causing a worldwide pandemic of severe and special infectious pneumonia (COVID-19). The increase in the number of infections and the death rate show that the virus has a very high transmission capacity and is very dangerous. Faced with such a dangerous agent, how do laboratory personnel protect themselves, and how to develop test reagents, antiviral drugs, and vaccines to fight against it? The speech will take you to understand the principle and operation of the P3 laboratory, and how does it help researchers to complete various tasks of new coronavirus research and development.